| Date | Location | Result | |
| 03/05/22 | Marietta, OH - Ban Johnson Arena | Marietta 88, Rochester 83 (OT) | Box score |
| 03/04/22 | Marietta, OH - Ban Johnson Arena | Rochester 88, Eastern 65 | Box score |
| 02/26/22 | Atlanta, GA - Woodruff PE Center | Emory 76, Rochester 74 | Box score |
| 02/23/22 | Alfred, NY - Orvis Gymnasium | Rochester 100, Alfred St. 66 | Box score |
| 02/20/22 | Rochester, NY - Louis Alexander Palestra | Rochester 80, Case Western Reserve 70 | Box score |
| 02/18/22 | Rochester, NY - Louis Alexander Palestra | Rochester 69, Carnegie Mellon 46 | Box score |
| 02/13/22 | St. Louis, MO - WU Field House | Rochester 72, Washington-St. Louis 71 | Box score |
| 02/11/22 | Chicago, IL - Ratner Athletics Center | Chicago 66, Rochester 62 | Box score |
| 02/06/22 | Waltham, MA - Red Auerbach Arena | Rochester 55, Brandeis 50 | Box score |
| 02/04/22 | Brooklyn, NY - Generoso Pope Complex | Rochester 75, NYU 65 | Box score |
| 01/30/22 | Rochester, NY - Louis Alexander Palestra | Brandeis 66, Rochester 61 | Box score |
| 01/28/22 | Rochester, NY - Louis Alexander Palestra | Rochester 74, NYU 70 (OT) | Box score |
| 01/23/22 | Cleveland, OH - Horsburgh Gymnasium | Case Western Reserve 74, Rochester 61 | Box score |
| 01/21/22 | Pittsburgh, PA - Weigand Gymnasium | Rochester 71, Carnegie Mellon 60 | Box score |
| 01/16/22 | Rochester, NY - Louis Alexander Palestra | Washington-St. Louis 70, Rochester 61 | Box score |
| 01/14/22 | Rochester, NY - Louis Alexander Palestra | Rochester 78, Chicago 52 | Box score |
| 01/08/22 | Rochester, NY - Louis Alexander Palestra | Emory 64, Rochester 61 | Box score |
| 01/05/22 | Buffalo, NY - Buffalo State Sports Arena | Rochester 99, Buffalo St. 57 | Box score |
| 12/07/21 | Ithaca, NY - Ben Light Gymnasium | Rochester 81, Ithaca 76 (OT) | Box score |
| 11/28/21 | Rochester, NY - Louis Alexander Palestra | Rochester 67, Olivet 48 | Box score |
| 11/27/21 | Rochester, NY - Louis Alexander Palestra | Rochester 72, Stockton 65 | Box score |
| 11/23/21 | Rochester, NY - Louis Alexander Palestra | Rochester 80, Hobart 57 | Box score |
| 11/20/21 | Pittsford, NY - Kidera Gymnasium | St. John Fisher 76, Rochester 60 | Box score |
| 11/18/21 | Pittsford, NY - Kidera Gymnasium | Nazareth 81, Rochester 73 | Box score |
| 11/13/21 | Rochester, NY - Louis Alexander Palestra | Rochester 80, Southern Va. 66 | Box score |
| 11/12/21 | Rochester, NY - Louis Alexander Palestra | Rochester 79, SUNY Cortland 53 | Box score |
| 11/09/21 | Rochester, NY - Louis Alexander Palestra | Rochester 68, SUNY Geneseo 56 | Box score |